Puntaftrek als gevolg van financiële tekortkomingen: FC Zwolle (1 punt), BV Veendam (4), SC Cambuur (3), MVV Maastricht (8), FC Dordrecht (4), AGOVV Apeldoorn (9), Fortuna Sittard (2), RBC Roosendaal (3), FC Omniworld (Almere City FC) (6).
RBC Roosendaal wordt na afloop van het seizoen failliet verklaard
FC Omniorld (Almere City FC), zou degraderen naar de Topklasse, maar handhaaft zich als gevolg van het faillissement van RBC Roosendaal.
Stand 2010/11
| Pos | Club | P | W | D | L | F | A | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  RKC Waalwijk | 34 | 22 | 7 | 5 | 85 | 40 | 45 | 73 |
| 2 |  PEC Zwolle | 34 | 20 | 10 | 4 | 69 | 27 | 42 | 69 |
| 3 |  Helmond Sport | 34 | 17 | 8 | 9 | 61 | 43 | 18 | 59 |
| 4 |  SC Veendam | 34 | 15 | 12 | 7 | 54 | 44 | 10 | 53 |
| 5 |  SC Cambuur | 34 | 15 | 9 | 10 | 64 | 52 | 12 | 51 |
| 6 |  FC Volendam | 34 | 14 | 9 | 11 | 56 | 50 | 6 | 51 |
| 7 |  Go Ahead Eagles | 34 | 13 | 11 | 10 | 58 | 43 | 15 | 50 |
| 8 |  FC Den Bosch | 34 | 11 | 14 | 9 | 56 | 47 | 9 | 47 |
| 9 |  Sparta Rotterdam | 34 | 12 | 7 | 15 | 71 | 65 | 6 | 43 |
| 10 |  MVV Maastricht | 34 | 14 | 8 | 12 | 44 | 50 | -6 | 42 |
| 11 |  FC Dordrecht | 34 | 12 | 9 | 13 | 52 | 56 | -4 | 41 |
| 12 |  FC Eindhoven | 34 | 10 | 10 | 14 | 41 | 49 | -8 | 40 |
| 13 |  FC Emmen | 34 | 8 | 11 | 15 | 48 | 64 | -16 | 35 |
| 14 |  Telstar | 34 | 8 | 10 | 16 | 43 | 54 | -11 | 34 |
| 15 |  AGOVV | 34 | 11 | 7 | 16 | 54 | 77 | -23 | 31 |
| 16 |  Fortuna Sittard | 34 | 7 | 7 | 20 | 42 | 70 | -28 | 26 |
| 17 |  RBC Roosendaal | 34 | 7 | 8 | 19 | 38 | 66 | -28 | 26 |
| 18 |  Almere City FC | 34 | 8 | 7 | 19 | 45 | 84 | -39 | 25 |
Promotie
Degradatie
Selectie 2010/11
Trainer Dick de Boer
- Nationaliteit
Nederland- Geboorte datum
- 28 dec. 1948
- Leeftijd
- 77
Assistent-trainer Edwin van Ankeren
- Nationaliteit
- Nederland
- Geboorte datum
- 13 aug. 1968
- Leeftijd
- 57
Keeper
| Speler |  | ||||||
|---|---|---|---|---|---|---|---|
| Erwin Friebel | 20 | 0 | 0 | 0 | 1 | 0 | 1651 |
 Kostas Peristeridis | 10 | 0 | 0 | 0 | 0 | 0 | 886 |
| Johan Jansen | 7 | 0 | 2 | 0 | 1 | 0 | 518 |
| Demi Loet-Loetoer | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Verdediger
| Speler | | ||||||
|---|---|---|---|---|---|---|---|
| Touvarno Pinas | 31 | 1 | 5 | 1 | 0 | 0 | 2732 |
| Dion Malone | 25 | 2 | 1 | 0 | 1 | 1 | 2039 |
| Renee Troost | 25 | 1 | 4 | 0 | 0 | 2 | 1961 |
| Donny Rijnink | 23 | 1 | 1 | 0 | 0 | 0 | 1347 |
| Mitchell Burgzorg | 12 | 5 | 2 | 0 | 0 | 0 | 1060 |
| Edwin Dekkers | 13 | 0 | 2 | 0 | 1 | 0 | 1007 |
| René Kofi | 9 | 0 | 2 | 0 | 1 | 0 | 631 |
| Mark Bevaart | 8 | 0 | 1 | 0 | 0 | 0 | 532 |
| Delano à Cohen | 5 | 1 | 0 | 0 | 0 | 0 | 368 |
Middenvelder
| Speler | | ||||||
|---|---|---|---|---|---|---|---|
| Jergé Hoefdraad | 32 | 1 | 2 | 0 | 0 | 0 | 2639 |
| Jonathan Robertson | 26 | 2 | 6 | 0 | 0 | 0 | 1666 |
| Richard van Heulen | 18 | 0 | 1 | 0 | 0 | 1 | 1510 |
| Paul de Lange | 10 | 1 | 2 | 0 | 1 | 0 | 820 |
| Marien Willemsen | 12 | 0 | 1 | 0 | 0 | 0 | 747 |
| Leroy Resodihardjo | 8 | 1 | 1 | 0 | 0 | 0 | 641 |
| Rik Schouw | 3 | 0 | 0 | 0 | 0 | 0 | 226 |
| Roy de Vries | 2 | 0 | 1 | 0 | 0 | 0 | 25 |
| Andy Simpe | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kevin van Os | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Aanvaller
| Speler | | ||||||
|---|---|---|---|---|---|---|---|
 Karim Fachtali | 33 | 11 | 1 | 0 | 0 | 0 | 2640 |
| Sidney Schmeltz | 33 | 4 | 6 | 0 | 0 | 0 | 2544 |
| Mikhail Rosheuvel | 26 | 5 | 0 | 0 | 0 | 0 | 1363 |
| Luciano Dompig | 19 | 1 | 4 | 0 | 1 | 0 | 1311 |
| Hanne Hagary | 21 | 2 | 3 | 0 | 1 | 0 | 1178 |
| Thijs Sluijter | 7 | 1 | 1 | 0 | 0 | 0 | 513 |
| Iwan Redan | 9 | 3 | 0 | 0 | 0 | 0 | 397 |
 Christian Gandu | 12 | 0 | 1 | 0 | 0 | 0 | 222 |
 Serdar Öztürk | 7 | 2 | 2 | 0 | 0 | 0 | 73 |
| Marvin Hasselbaink | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Jeffrey Dekker | 0 | 0 | 0 | 0 | 0 | 0 | 0 |